Alternatives to Ascites Production of Monoclonal Antibodies: Table 1. Antibody production in different bioreactor systems - Alternatives to Animal Research and Testing - Articles and Reports From Stop Animal Exploitation NOW! (SAEN)

Home Page
About SAEN
Articles and Reports
Contact Us
Events and Campaigns
Fact Sheets
Financial Information
How You Can Help
Make a Donation, Please!
Media Coverage
Newsletters
Petitions
Picture Archive
Press Releases
Resources and Links
Grass Roots Org. List

Stop Animal Exploitation NOW!
S. A. E. N.
"Exposing the truth to wipe out animal experimentation"

Articles and Reports

Alternatives to Animal Research and Testing

Alternatives to Ascites Production of Monoclonal Antibodies
by John McArdle, Ph.D.
Alternatives Research and Development Foundation
Eden Prairie, Minnesota
www.nal.usda.gov/awic/newsletters/v8n3/8n3mcard.htm

Table 1. Antibody production in different bioreactor systems

Table 1. Antibody production in different bioreactor systems (Adapted from Stoll et al., 1995 (24)).
System	Maximum Concentration	Productivity	Required for the production of 1 g
In vivo	2200	2	180 mice
In vitro
T-flask	42	7	400 T-flasks
Stirred-tank bioreactor, batch	47	180^a	39 days
Stirred-tank bioreactor, fed-batch	120	250^a	28 days
Hollow fiber reactor	1600	1400	26; 5 days^b
^aThe total cycle time (innoculation, culture and cleaning) was taken into account. ^bFirst number is for first gram; second number is for second gram.

Go on to Table 2. Comparisons of different monoclonal production methods
Return to Alternatives to Ascites Production of Monoclonal Antibodies
Return to Alternatives to Animal Research and Testing
Return to Articles and Reports

Fair Use Notice: This document may contain copyrighted material whose use has not been specifically authorized by the copyright owners. We believe that this not-for-profit, educational use on the Web constitutes a fair use of the copyrighted material (as provided for in section 107 of the US Copyright Law). If you wish to use this copyrighted material for purposes of your own that go beyond fair use, you must obtain permission from the copyright owner

We welcome your comments and questions

Our education and humane efforts include: abuse, animal, animals, AWA, awa, Animal Welfare Act, animal welfare act, ape, apes, baboon, cat, cats, cruelty, dog, dogs, education, experiment, experiments, experimentation, exploitation, freedom, guinea, humane, lab, labs, laboratory, laboratories, liberation, macaque, medical, mice, monkey, monkeys, pig, pigs, primate, primates, rabbit, rabbits, rat, rats, research, researcher, researchers, right, rights, SAEN, saen, squirrel, testing, vivisection, welfare