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Resources and Links
US Government Department of Defense
DoD Biomedical Research Database Search Results - 2007
|
Title: |
Electrophysiological,
Behavioral And Genetic Indicators Of Cognitive Performance
Deficits Associate With Sleep-Deprivation In Nonhuman
Primates: Assessment & Prevention |
|
Research Category: |
N4: Neural Science
|
| FY:
2005 Funding (in dollars):
|
645,259 |
|
Responsible Organization: |
DEFENSE ADVANCED RESEARCH
PROJECTS AGENCY |
| Primary
Contact: |
Public Affairs Office
|
| City:
|
Arlington |
| State:
|
VA |
| Zip:
|
22203-1714 |
|
Keywords: |
LABORATORY
ANIMALS SLEEP DEPRIVATION
ELECTROPHYSIOLOGICAL SHORT-TERM MEMORY IMAGING
|
|
Objective: |
The primary testing
component of the project consists of a non human primate
model which employs many-neuron recording techniques to
assess changes in identified neural ensemble correlates of
short-term memory and motor performance during sleep
deprivation. Parallel assessment and identification of
regional brain metabolic changes following sleep
deprivation, utilizing Positron Emission Tomography (PET),
will be conducted in the same nonhuman primates, providing
a powerful complementary approach for determining key
brain areas susceptible to change during sleep
deprivation. The identification of genomic changes that
accompany sleep deprivation in rodents, comparing these
changes to the deleterious effects of stress. The latter
component will serve as a basis for developing
molecular/pharmacological agents that reduce these
effects. |
|
Approach: |
This research project will
characterize attenuate and potentially alleviate the
deleterious effects of sleep deprivation in non human
primates engaged in tasks requiring precise motor
responses based on short-term memory. The Project will
identify, in the same nonhuman primates, those brain
regions that are altered during prolonged sleep
deprivation, using sophisticated electrophysiological
recording techniques coupled with non invasive imaging
methods, and will provide the first complete description
of genomic changes associated with long periods of sleep
deprivation |
|
|
Research was conducted in compliance with the
Animal Welfare Act and other Federal statutes and regulations relating to the
use of animals in research and was reviewed and approved by the Institute's
Animal Care and Use Committee.
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