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U.S. Army Medical Research, Frederick, MD
DOD Funding of Animal Cruelty 2005:
M2: Infectious Diseases - 1
Title: Development of a nonhuman primate model for aerosol
exposure to Ebola virus.
Research Category: M2: Infectious Diseases
FY: 2005 Funding (in dollars): $100,000
Responsible Organization: U.S. ARMY MEDICAL RESEARCH INSTITUTE
OF INFECTIOUS DISEASES
Primary Contact: MRMC: U.S. Army Medical Research Institute of
City: Fort Detrick
Keywords: LABORATORY ANIMALS EBOLA
The objective of this protocol is to develop NHP models for aerosol
exposure to EBOV. The first step in this development is to use the
staircase method to measure the response of NHP to infection by varying
doses of aerosolized virus. The median lethal dose (LD for aerosolized
ZEBOV will be determined in the cynomolgus macaque. Following
determination of the LD5O, a small group of animals will be exposed to
low and high lethal doses of ZEBOV in order to collect data concerning
the disease course and clinical signs of ZEBOV infection, data which
will be important for future vaccine efficacy studies Based on prior and
ongoing studies with MARV and personal communicat10ns from Russian
scientists, we hypothesize that the LD5O of aerosolized ZEBOV will be
higher than what is thought to be the LOSO of ZEBOV by a parenteral
route (? 1 pfu). These experiments will then be repeated with SEBOV.
Finally, we will look at the outcome of aerosol exposure in rhesus
macaques and African greens to compare and contrast differences in
disease course and outcome with the cynomolgus macaque.
Ebola viruses (EBOV) are highly infectious by aerosol and are considered
a potential biological warfare threat against U.S. Armed Forces. In
order to test candidate vaccines, animal models are needed for aerosol
exposure to EBOV Nonhuman primates (NHP) are the closest animal models
to humans, and the Reed,A05-02disease course and outcome of many
diseases are similar be primates and humans. This protocol will begin
the development of a NHP model of aerosol exposure to EBOV for use in
vaccine efficacy studies. This protocol will determine the challenge
dose to be used for future vaccine studies and examine clinical signs of
exposure (fever, pulse, blood pressure changes in white blood cells,
blood clothn9 and liver en to determine what if any signs can predict
the outcome of infection. In addition, we will assess three different
species of NHP in order to establish the most appropriate model of human
Research was conducted in compliance with the Animal Welfare Act and
other Federal statutes and regulations relating to the use of animals in
research and was reviewed and approved by the Institute's Animal Care
and Use Committee.
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Rats, mice, birds, amphibians and other animals have been excluded from coverage by the Animal Welfare Act. Therefore research facility reports do not include these animals. As a result of this situation, a blank report, or one with few animals listed, does not mean that a facility has not performed experiments on non-reportable animals. A blank form does mean that the facility in question has not used covered animals (primates, dogs, cats, rabbits, guinea pigs, hamsters, pigs, sheep, goats, etc.). Rats and mice alone are believed to comprise over 90% of the animals used in experimentation. Therefore the majority of animals used at research facilities are not even counted.