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U.S. Army Medical Research, Frederick, MD
DOD Funding of Animal Cruelty 2005:
M2: Infectious Diseases - 3
Title: Demonstration of a Novel Real-Time Dosimetric Nose-Only
Inhalation Exposure System using Guinea Pigs and Mice
Research Category: M2: Infectious Diseases
FY: 2005 Funding (in dollars): $30,000
Responsible Organization: U.S. ARMY MEDICAL RESEARCH INSTITUTE
OF INFECTIOUS DISEASES
Primary Contact: MRMC: U.S. Army Medical Research Institute of
City: Fort Detrick
Keywords: LABORATORY ANIMALS AEROSOL
The objective of this study is to determine if the newly-designed rodent
nose-only tower can deliver multiple doses at the same time and to
compare the performance of the new system to the in-use system at
USAMRIID. In addition to testing the proof of concept, the following
specific hypothesis (HO) will be addressed: HOl: There is no difference
in the variance of measurement of aerosol concentration parameters
between the in-use and newly designed system.
Non-technical Synopsis: Exposing animals to inhaled biological aerosols ?bioaerosols?
usually imparts a mechanical process by which animal(s) are exposed to
an experimental atmosphere which is breathed for a specific amount of
time. The bioaerosol concentration in the experimental atmosphere is
then multiplied with the total amount of air the animal breathed (or
assumed to breathe) during the prescribed time of exposure to estimate
an ?inhaled? dose of substance. presently, the inhaled dose received by
rodents is calculated based on certain biological assumptions rather
than measured. In addition, animal groups receiving different dosages
are exposed during discrete ?runs? of the system. This study will test a
new exposure system that has been designed to reduce identified sources
of variation inherent with the present in-use system. The new system
will be compared to the in-use aerosol system by exposing an equal
number of mice and guinea pigs to varying doses of aerosolized ricin
using either system. The older system will use predetermined time based
on group assumptions; the newer system will rely on the respiratory
function of each animal during the exposure paired with real-time
aerosol monitoring to determine the dose for each animal. Because this
is a completely new technology, this effort represents a preliminary
comparison study between the older system and a newly-designed system.
It is expected that the new system will improve the accuracy and
precision of research requiring inhalation exposure to bioaerosols,
ultimately improving the screening of medical countermeasures in in vivo
models where aerosol challenge is obligatory.
Research was conducted in compliance with the Animal Welfare Act and
other Federal statutes and regulations relating to the use of animals in
research and was reviewed and approved by the Institute's Animal Care
and Use Committee.
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Rats, mice, birds, amphibians and other animals have been excluded from coverage by the Animal Welfare Act. Therefore research facility reports do not include these animals. As a result of this situation, a blank report, or one with few animals listed, does not mean that a facility has not performed experiments on non-reportable animals. A blank form does mean that the facility in question has not used covered animals (primates, dogs, cats, rabbits, guinea pigs, hamsters, pigs, sheep, goats, etc.). Rats and mice alone are believed to comprise over 90% of the animals used in experimentation. Therefore the majority of animals used at research facilities are not even counted.