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U.S. Army Medical Research, Frederick, MD
DOD Funding of Animal Cruelty 2005:
M4: Medical Biological Defense - 1
Title: Comparing Ricin Intoxication from Two Distinct Particle
Sizes in the Guinea Pig and Nonhuman Primate Models in Support of
Research Category: M4: Medical Biological Defense
FY: 2005 Funding (in dollars): $60,000
Responsible Organization: U.S. ARMY MEDICAL RESEARCH INSTITUTE
OF INFECTIOUS DISEASES
Primary Contact: MRMC: U.S. Army Medical Research Institute of
City: Fort Detrick
Keywords: LABORATORY ANIMALS RICIN
1) Use two distinct size distributions of ricin to compare deposition
and distribution of inhaled small and large particle sizes. These
studies will identify both common and divergent mechanisms of toxin
pathogenesis and lead to well-characterized rodent and NHP models for
vaccine trials involving mixed agent exposures. The aerosol LD5O will be
established and disease course described for each model, at each
particle size. 2) Correlate differences in aerosol particle size to
pathogenesis by comparing time to infection/lethality, toxin load in
blood/tissue, and immunoreactivity and anatomic distribution of the
toxin in tissue. This will allow better estimates regarding the human
response to medical countermeasures. 3) Refine the models by collecting
clinical observations which will define earlier endpoints for
euthanasia, thereby reducing discomfort and/or pain to animals.
Ricin is a toxin that, when inhaled, will cause severe lung disease and
death. Well developed animal models of disease are needed to determine
if vaccines or medications for ricin toxin exposure will be effective in
humans. Developing aerosol models for ricin intoxication is important
because inhalation is the most likely route of exposure. Many of the
products under development are presently not tested using an aerosol
challenge simply because of the absence of a defined model. This
protocol will establish a valid model to fill this research
Research was conducted in compliance with the Animal Welfare Act and
other Federal statutes and regulations relating to the use of animals in
research and was reviewed and approved by the Institute's Animal Care
and Use Committee.
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Rats, mice, birds, amphibians and other animals have been excluded from coverage by the Animal Welfare Act. Therefore research facility reports do not include these animals. As a result of this situation, a blank report, or one with few animals listed, does not mean that a facility has not performed experiments on non-reportable animals. A blank form does mean that the facility in question has not used covered animals (primates, dogs, cats, rabbits, guinea pigs, hamsters, pigs, sheep, goats, etc.). Rats and mice alone are believed to comprise over 90% of the animals used in experimentation. Therefore the majority of animals used at research facilities are not even counted.