U.S. Army Medical Research, Frederick, MD

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U.S. Army Medical Research, Frederick, MD

DOD Funding of Animal Cruelty 2005:
M4: Medical Biological Defense - 1

Title: Comparing Ricin Intoxication from Two Distinct Particle Sizes in the Guinea Pig and Nonhuman Primate Models in Support of Medical Countermeasures

Research Category: M4: Medical Biological Defense

FY: 2005 Funding (in dollars): $60,000

Responsible Organization: U.S. ARMY MEDICAL RESEARCH INSTITUTE OF INFECTIOUS DISEASES

Primary Contact:
MRMC: U.S. Army Medical Research Institute of Infectious Diseases
City: Fort Detrick
State: MD
Zip: 21702-5011

Keywords: LABORATORY ANIMALS RICIN

Objective:
1) Use two distinct size distributions of ricin to compare deposition and distribution of inhaled small and large particle sizes. These studies will identify both common and divergent mechanisms of toxin pathogenesis and lead to well-characterized rodent and NHP models for vaccine trials involving mixed agent exposures. The aerosol LD5O will be established and disease course described for each model, at each particle size. 2) Correlate differences in aerosol particle size to pathogenesis by comparing time to infection/lethality, toxin load in blood/tissue, and immunoreactivity and anatomic distribution of the toxin in tissue. This will allow better estimates regarding the human response to medical countermeasures. 3) Refine the models by collecting clinical observations which will define earlier endpoints for euthanasia, thereby reducing discomfort and/or pain to animals.

Approach:
Ricin is a toxin that, when inhaled, will cause severe lung disease and death. Well developed animal models of disease are needed to determine if vaccines or medications for ricin toxin exposure will be effective in humans. Developing aerosol models for ricin intoxication is important because inhalation is the most likely route of exposure. Many of the products under development are presently not tested using an aerosol challenge simply because of the absence of a defined model. This protocol will establish a valid model to fill this research gap.Leffel,A05-05 ________________________________________

Research was conducted in compliance with the Animal Welfare Act and other Federal statutes and regulations relating to the use of animals in research and was reviewed and approved by the Institute's Animal Care and Use Committee.

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Rats, mice, birds, amphibians and other animals have been excluded from coverage by the Animal Welfare Act. Therefore research facility reports do not include these animals. As a result of this situation, a blank report, or one with few animals listed, does not mean that a facility has not performed experiments on non-reportable animals. A blank form does mean that the facility in question has not used covered animals (primates, dogs, cats, rabbits, guinea pigs, hamsters, pigs, sheep, goats, etc.). Rats and mice alone are believed to comprise over 90% of the animals used in experimentation. Therefore the majority of animals used at research facilities are not even counted.

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