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U.S. Army Medical Research, Frederick, MD
DOD Funding of Animal Cruelty 2005:
M4: Medical Biological Defense - 5
Title: Protective efficacy of live attenuated anthrax vaccines in
Research Category: M4: Medical Biological Defense
FY: 2005 Funding (in dollars): $20,000
Responsible Organization: U.S. ARMY MEDICAL RESEARCH INSTITUTE
OF INFECTIOUS DISEASES
Primary Contact: MRMC: U.S. Army Medical Research Institute of
City: Fort Detrick
Keywords: LABORATORY ANIMALS B. ANTHRACIS
Preliminary data shows that capsule provided by an attenuated
PA-producing vaccine strain increases guinea pig survival when compared
to the same strain producing only PA. The objectives of this research
are to confirm protection by the encapsulated strain and compare
efficacy to the current approved human vaccine (AvA), the next
generation vaccine (rPA), and to the licensed animal vaccine (B.
Preliminary work with guinea pigs suggests that a weakened B. anthracis
strain induces better immunity when it has a capsule than when it does
not. We propose to compare protection in guinea pigs given the
encapsulated strain with the currently licensed protein vaccine (AVA),
an improved protein vaccine (rPA), and the licensed animal vaccine (B.
Research was conducted in compliance with the Animal Welfare Act and
other Federal statutes and regulations relating to the use of animals in
research and was reviewed and approved by the Institute's Animal Care
and Use Committee.
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Rats, mice, birds, amphibians and other animals have been excluded from coverage by the Animal Welfare Act. Therefore research facility reports do not include these animals. As a result of this situation, a blank report, or one with few animals listed, does not mean that a facility has not performed experiments on non-reportable animals. A blank form does mean that the facility in question has not used covered animals (primates, dogs, cats, rabbits, guinea pigs, hamsters, pigs, sheep, goats, etc.). Rats and mice alone are believed to comprise over 90% of the animals used in experimentation. Therefore the majority of animals used at research facilities are not even counted.