Walter Reed Army Institute of Research, Silver Spring, MD

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Walter Reed Army Institute of Research, Silver Spring, MD

DOD Funding of Animal Cruelty 2005:
C1: Clinical Medicine - 1

Title: A Comparison of Topically Applied Tropicamide vs Tropicamide plus Phenylephrine HCl vs Tropicamide plus Phenylephrine HCl plus Cyclopentolate for pupillary dilation in Rhesus, Cynomologous, and African Green Monkeys

Research Category: C1: Clinical Medicine

FY: 2005 Funding (in dollars):  $128210

Responsible Organization: WALTER REED ARMY INSTITUTE OF RESEARCH
Primary Contact: Walter Reed Army Institute of Research
City: Silver Spring
State: MD
Zip: 20910-7500

Keywords: LABORATORY ANIMALS MYDRIASIS DILATION CYCLOPLEGIA

Objective:
The primary objective of this study is to determine if the size of pupillary dilation is statistically different when comparing TP or TPC with tropicamide alone in the nonhuman primate. The secondary objectives for this study are: ? To determine the average length of time to maximum pupillary dilation for each of the three drug regimens. ? To determine the average duration of pupillary dilation for each of the three drug regimens. ? To compare which dilation treatment is most effective for each species of nonhuman primate utilized in this study.

Approach:
The use of combination topical therapies for pupillary dilation in nonhuman primates has been described anecdotally. However the efficacy of treatment has not been documented or published. This study should determine a drug regimen that provides an effective and consistent pupillary dilation for nonhuman primate eye examinations. This protocol will utilize nonhuman primates separated into three (3) groups by species i.e. group 1: Rhesus, group 2: Cynomolgous, and group 3: African Green monkey. Animals will be sedated in their home cage and moved to a study room where physiologic parameters will be recorded during the course of data collection. Baseline pupil diameter will be measured with vernier calipers and recorded for each eye. Then one drop from each agent of a dilation drug regimen will be placed in each eye (time zero). Pupillary diameter of each eye will be measured post-eye drop instillation till maximum dilation has been reached and pupil size has decreased in two consecutive measurements, whichever comes first. Animals will be returned to their home cage and continuously monitored until recovered from sedation. Data from groups 1, 2, and 3 will be used to determine effectiveness, variability and comparability between the drug regimen methods and nonhuman primate species.
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Research was conducted in compliance with the Animal Welfare Act and other Federal statutes and regulations relating to the use of animals in research and was reviewed and approved by the Institute's Animal Care and Use Committee.

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Rats, mice, birds, amphibians and other animals have been excluded from coverage by the Animal Welfare Act. Therefore research facility reports do not include these animals. As a result of this situation, a blank report, or one with few animals listed, does not mean that a facility has not performed experiments on non-reportable animals. A blank form does mean that the facility in question has not used covered animals (primates, dogs, cats, rabbits, guinea pigs, hamsters, pigs, sheep, goats, etc.). Rats and mice alone are believed to comprise over 90% of the animals used in experimentation. Therefore the majority of animals used at research facilities are not even counted.

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