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Facility Reports and Information
Walter Reed Army Institute of Research, Silver Spring, MD
DOD Funding of Animal Cruelty 2005:
C1: Clinical Medicine - 1
Title: A Comparison of Topically Applied Tropicamide vs
Tropicamide plus Phenylephrine HCl vs Tropicamide plus Phenylephrine HCl
plus Cyclopentolate for pupillary dilation in Rhesus, Cynomologous, and
African Green Monkeys
Research Category: C1: Clinical Medicine
FY: 2005 Funding (in dollars): $128210
Responsible Organization: WALTER REED ARMY INSTITUTE OF
Primary Contact: Walter Reed Army Institute of Research
City: Silver Spring
Keywords: LABORATORY ANIMALS MYDRIASIS DILATION CYCLOPLEGIA
The primary objective of this study is to determine if the size of
pupillary dilation is statistically different when comparing TP or TPC
with tropicamide alone in the nonhuman primate. The secondary objectives
for this study are: ? To determine the average length of time to maximum
pupillary dilation for each of the three drug regimens. ? To determine
the average duration of pupillary dilation for each of the three drug
regimens. ? To compare which dilation treatment is most effective for
each species of nonhuman primate utilized in this study.
The use of combination topical therapies for pupillary dilation in
nonhuman primates has been described anecdotally. However the efficacy
of treatment has not been documented or published. This study should
determine a drug regimen that provides an effective and consistent
pupillary dilation for nonhuman primate eye examinations. This protocol
will utilize nonhuman primates separated into three (3) groups by
species i.e. group 1: Rhesus, group 2: Cynomolgous, and group 3: African
Green monkey. Animals will be sedated in their home cage and moved to a
study room where physiologic parameters will be recorded during the
course of data collection. Baseline pupil diameter will be measured with
vernier calipers and recorded for each eye. Then one drop from each
agent of a dilation drug regimen will be placed in each eye (time zero).
Pupillary diameter of each eye will be measured post-eye drop
instillation till maximum dilation has been reached and pupil size has
decreased in two consecutive measurements, whichever comes first.
Animals will be returned to their home cage and continuously monitored
until recovered from sedation. Data from groups 1, 2, and 3 will be used
to determine effectiveness, variability and comparability between the
drug regimen methods and nonhuman primate species.
Research was conducted in compliance with the Animal Welfare Act and
other Federal statutes and regulations relating to the use of animals in
research and was reviewed and approved by the Institute's Animal Care
and Use Committee.
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Rats, mice, birds, amphibians and other animals have been excluded from coverage by the Animal Welfare Act. Therefore research facility reports do not include these animals. As a result of this situation, a blank report, or one with few animals listed, does not mean that a facility has not performed experiments on non-reportable animals. A blank form does mean that the facility in question has not used covered animals (primates, dogs, cats, rabbits, guinea pigs, hamsters, pigs, sheep, goats, etc.). Rats and mice alone are believed to comprise over 90% of the animals used in experimentation. Therefore the majority of animals used at research facilities are not even counted.