University of Michigan, Ann Arbor, MI

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Stop Animal Exploitation NOW!
S. A. E. N.
"Exposing the truth to wipe out animal experimentation"

Government Grants Promoting Cruelty to Animals

University of Michigan, Ann Arbor, MI

JAMES H. WOODS - Primate Testing - 2007

Grant Number: 5R01DA021416-02
Project Title: Development of Esterases for the Treatment of Cocaine Overdose and Abuse
PI Information: PROFESSOR JAMES H. WOODS, jhwoods@umich.edu 

Abstract: DESCRIPTION (provided by applicant): Cocaine esterase (CocE) is a product of the bacterium Rhodococcus sp. which grows in the rhizosphere of coca plants in South America. The bacterium uses cocaine as its sole source of carbon and nitrogen, synthesizing CocE to initiate metabolism of the cocaine CocE is the most efficient enzyme (7.2 X 108) for metabolizing cocaine yet identified. It can both prevent and reverse extreme cocaine toxicity in our rodent models, and it has the potential to be developed into the first useful antagonist of cocaine's toxic effects. This proposal contains studies to continue to evaluate this enzyme in mouse and rat models of cocaine toxicity, to compare its effects with other protein-based anti-cocaine enzymes, and to use a variety of in vitro techniques, including pegylation and insertion into red blood cells, to improve this or other enzymes by reducing their antigenicity, and heat liability. These procedures are designed to prolong the enzyme's duration of action with the hopeful outcome that some insight will be obtained into how to make this substance useful in the long-term treatment of cocaine abuse.

Thesaurus Terms:
There are no thesaurus terms on file for this project.

Institution:
UNIVERSITY OF MICHIGAN AT ANN ARBOR
3003 SOUTH STATE STREET, Room 1040
ANN ARBOR, MI 48109
Fiscal Year: 2007
Department: PHARMACOLOGY   
Project Start: 10-MAY-2006  
Project End: 30-APR-2010
ICD: NATIONAL INSTITUTE ON DRUG ABUSE
IRG: NIDA

Please email:  JAMES H. WOODS, jhwoods@umich.edu  to protest the inhumane use of animals in this experiment. We would also love to know about your efforts with this cause: saen@saenonline.org

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Rats, mice, birds, amphibians and other animals have been excluded from coverage by the Animal Welfare Act. Therefore research facility reports do not include these animals. As a result of this situation, a blank report, or one with few animals listed, does not mean that a facility has not performed experiments on non-reportable animals. A blank form does mean that the facility in question has not used covered animals (primates, dogs, cats, rabbits, guinea pigs, hamsters, pigs, sheep, goats, etc.). Rats and mice alone are believed to comprise over 90% of the animals used in experimentation. Therefore the majority of animals used at research facilities are not even counted.

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