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Air Force Research Laboratory, Wright-Patterson AFB, OH
DOD Funding of Animal Cruelty 2005: CAP Study (OSMSWP02)
Title: CAP Study (OSMSWP02)
FY: 2005 Funding (in dollars): 117,000
Responsible Organization: AIR FORCE RESEARCH LAB/WRIGHT
Primary Contact: See Responsible Organization Information
City: Wright-Patterson AFB
Keywords: LABORATORY ANIMALS CAPSAICIN IRRITATION EYE OCULAR
Objective: The purpose of this study is to determine and
evaluate the reaction of a protein as an antidote following capsaicin
exposure of the rabbit eye. The hypothesis is that the protein will
reverse capsaicin-induced irritation symptoms. The evaluation includes
gathering time-dependent and concentration-dependent data and results.
Questions related to effectiveness of single vs. multiple applications,
impact of manufacturer/lot number on the potency of the protein, and
effectiveness of the protein used prior to capsaicin exposure need to be
investigated for a thorough evaluation process.
Approach: Capsaicin is the irritating agent in pepper spray.
Capsaicin is obtained from oleoresin capsicum found in red peppers.
Capsaicin causes irritation of the eye. Pepper spray is a non-lethal
weapon but its use is limited due to the potential for irritation to the
personnel using it. The purpose of this study is to test a protein
compound that appears to prevent and reverse eye irritation caused by
capsaicin. The use of the protein compound in this manner is protected
under a signed non-disclosure agreement between the Air Force and an
outside third party. The study will look at exposures of the rabbit eye,
the model for eye irritation in toxicology. The study includes a series
of phases designed to examine time and concentration issues for both the
protein and the capsaicin. The first phase tests the protein by itself
to ensure that it will not cause any irritation to rabbit eyes either in
a single or repeated application. Additional phases will confirm the
amount of capsaicin that produces a mild irritation (phase 2) and the
optimum amount of the protein that prevents the irritation (phase 3).
Other issues are whether anesthesia effects eye irritation response
(also phase 3), the source of the protein on the effectiveness to block
irritation (phase 4), the effects of multiple exposures to both the
capsaicin and protein compound (phase 5) and whether the protein can be
administered prior to the capsaicin and still be effective (phase 6).
One eye of each rabbit will be exposed and the other eye will serve as
the control eye for comparison of effect.
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Rats, mice, birds, amphibians and other animals have
been excluded from coverage by the Animal Welfare Act. Therefore research
facility reports do not include these animals. As a result of this
situation, a blank report, or one with few animals listed, does not mean
that a facility has not performed experiments on non-reportable animals. A
blank form does mean that the facility in question has not used covered
animals (primates, dogs, cats, rabbits, guinea pigs, hamsters, pigs,
sheep, goats, etc.). Rats and mice alone are believed to comprise over 90%
of the animals used in experimentation. Therefore the majority of animals
used at research facilities are not even counted.