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Air Force Research Laboratory, Wright-Patterson AFB, OH
DOD Funding of Animal Cruelty 2005: The Acute Effects of Tungsten Alloys on the Airways of Sprague-Dawley Rats (Rattus norvegicu)
Title: The Acute Effects of Tungsten Alloys on the Airways of
Sprague-Dawley Rats (Rattus norvegicu)
FY: 2005 Funding (in dollars): 91,000
Responsible Organization: AIR FORCE RESEARCH LAB/WRIGHT
Primary Contact: See Responsible Organization Information
City: Wright-Patterson AFB
Keywords: LABORATORY ANIMALS TUNGSTEN ALLOYS TUNGSTEN, NICKEL
AND COBALT CO-EXPOSURE, INHALATION AEROSOL INTRATRACHEAL INSTILLATION
LUNG INFLAMMATION LUNG INJURY TUNGSTEN
Objective: Determine if the persistent airway inflammation
observed following a single exposure to tungsten alloys is associated
with genotoxic changes and tumor development.
Approach: Adult sprague Dawley rats were intra-tracheally
exposed to four different analytes; Tungsten-Nickel-Cobalt (WA1),
Tungsten-Nickel-Iron (WA2), Silica (positive response), Titanium dioxide
(particle control). These were then grouped into various doses (low,
medium, and high) with various times for exposure (24 hour, 3 days, 7
days, 3 months, and 6 months). Macrophage counts were done with lung
lavages as well as various cytokine response tests, histopathology, and
metal analyses of various tissues.
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Rats, mice, birds, amphibians and other animals have
been excluded from coverage by the Animal Welfare Act. Therefore research
facility reports do not include these animals. As a result of this
situation, a blank report, or one with few animals listed, does not mean
that a facility has not performed experiments on non-reportable animals. A
blank form does mean that the facility in question has not used covered
animals (primates, dogs, cats, rabbits, guinea pigs, hamsters, pigs,
sheep, goats, etc.). Rats and mice alone are believed to comprise over 90%
of the animals used in experimentation. Therefore the majority of animals
used at research facilities are not even counted.