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Air Force Research Laboratory, Wright-Patterson AFB, OH
DOD Funding of Animal Cruelty 2005: Continuing
Development of a Tissue Based Biosensor (TBB) using Rats, Mice and Fish
Title: Continuing Development of a Tissue Based Biosensor (TBB)
using Rats, Mice and Fish
FY: 2005 Funding (in dollars): 60,000
Responsible Organization: AIR FORCE RESEARCH LAB/WRIGHT
Primary Contact: See Responsible Organization Information
City: Wright-Patterson AFB
Keywords: LABORATORY ANIMALS TISSUE BASED BIOSENSOR (TBB)
CHEMICAL TOXICANTS STRESSORS MICROARRAYS
Objective: To develop a tissue-based biosensor (a biosensor
using living tissue) with the capability of responding to a wide range
of chemical toxicants or stressors.
Approach: The protocol describes the use of living central
nervous system (CNS) tissue slices from mouse, rat or bluegill sunfish
for application to existing 64-electrode microarrays that measure a wide
range of changes in the electrical responsivity of tissue slices. It is
hypothesized that living tissue slices adhered to (acute applications)
or cultured on (long-term applications) microarrays can be successfully
used to recognize and/or identify chemicals and other stressors with the
capacity for human risk. It is further hypothesized that such tissue
based biosensors can be cost-effectively used to detect chemical
toxicants and stressors at concentrations well below those sufficient to
induce human histopathology.
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Rats, mice, birds, amphibians and other animals have
been excluded from coverage by the Animal Welfare Act. Therefore research
facility reports do not include these animals. As a result of this
situation, a blank report, or one with few animals listed, does not mean
that a facility has not performed experiments on non-reportable animals. A
blank form does mean that the facility in question has not used covered
animals (primates, dogs, cats, rabbits, guinea pigs, hamsters, pigs,
sheep, goats, etc.). Rats and mice alone are believed to comprise over 90%
of the animals used in experimentation. Therefore the majority of animals
used at research facilities are not even counted.