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Facility Reports and Information

Air Force Research Laboratory, Wright-Patterson AFB, OH

DOD Funding of Animal Cruelty 2005: Characterization of Reproductive Toxicity of Depleted Uranium in Rats

Title: Characterization of Reproductive Toxicity of Depleted Uranium in Rats

Research Category:

FY: 2005 Funding (in dollars): 125,000

Responsible Organization: AIR FORCE RESEARCH LAB/WRIGHT PATTERSON
Primary Contact: See Responsible Organization Information
City: Wright-Patterson AFB
State: OH
Zip: 45433-7902

Keywords: LABORATORY ANIMALS DEPLETED URANIUM REPRODUCTIVE STUDY DEVELOPMENTAL STUDY PELLET IMPLANTATION

Objective: To determine the effects of surgically implanted depleted uranium (DU) pellets on adult rat reproductive success and development across two successive generations.

Approach: Adult rats were surgically implanted with DU or control of differing amounts and the P1 generation was then cross-mated at 30d post surgical implantation. DU was collected from the animals to determine the amount of DU excreted. Additionally, animals were monitored for reproductive success, survival or body weigh gain through surgical implantation day 90. Neurodevelopment and immune function assessments were also conducted on F1 offspring

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Rats, mice, birds, amphibians and other animals have been excluded from coverage by the Animal Welfare Act. Therefore research facility reports do not include these animals. As a result of this situation, a blank report, or one with few animals listed, does not mean that a facility has not performed experiments on non-reportable animals. A blank form does mean that the facility in question has not used covered animals (primates, dogs, cats, rabbits, guinea pigs, hamsters, pigs, sheep, goats, etc.). Rats and mice alone are believed to comprise over 90% of the animals used in experimentation. Therefore the majority of animals used at research facilities are not even counted.

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