Air Force Research Labs, Brooks Air Force Base, TX

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Air Force Research Labs, Brooks Air Force Base, TX

DOD Funding of Animal Cruelty 2005:
N1: Physical Protection - 1

Title: Evaluation of a New Non-human Primate Model for Investigation of Laser-Induced Retinal Damage: Mechanism of Retinal Damage from Laser Exposure in both Rhesus (Macaca mulatta) and Cynomolgus (Macaca fascicularis) Monkeys

Research Category: N1: Physical Protection

FY: 2005 Funding (in dollars): $520,356

Responsible Organization: AIR FORCE RESEARCH LAB/BROOKS
Primary Contact: Air Force Research Laboratory
City: Brooks City-Base
State: TX
Zip: 78235-5116


Objective: To collect retinal damage threshold data and to examine the pathology of retinal tissues in cynomolgus monkeys under selected laser exposure conditions for which the analogous determinations have already been conducted in the rhesus monkey. To ascertain via these ?bridging? studies whether or not the Cynomolgus monkey would be a suitable alternative to the rhesus for future studies.

Approach: The great majority of the experimental data base upon which DOD and national laser safety standards are based, consists of ED50 damage thresholds obtained using the rhesus monkey (Macaca mulatta) as an animal model. Due to the increased need by the human/simian retrovirus research community, in the investigation of AIDS, Indian Origin Rhesus Monkeys have become extremely difficult to obtain. This protocol is proposed as the first of a series of ?bridging? studies which is collecting retinal damage threshold data from an alternative primate model ? the Cynomolgus (Macaca fascicularis) whose projected availability and cost could alleviate the problems associated with the continued use of rhesus subjects for such studies. The experiments are structured in such a way as to continue to collect limited threshold and damage mechanism data pertinent to laser safety standard issues from the few available rhesus, while replicating the experiments for several key laser exposure parameters in the Cynomolgus. The protocol is extending the studies of new damage mechanisms and multiple-pulse cumulative effects by assessing multiple-pulse (single pulse to 30 kHz) damage thresholds for trains of 5 nsec, 1064 um pulses. The nature of the additivity of multiple-pulse exposures will be contrasted with published results and safety standard treatments for repetitive-pulse exposures (for comparable wavelength and pulse repetition frequencies).  

Research was conducted in compliance with the Animal Welfare Act and other Federal statutes and regulations relating to the use of animals in research and was reviewed and approved by the Institute's Animal Care and Use Committee.

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Rats, mice, birds, amphibians and other animals have been excluded from coverage by the Animal Welfare Act. Therefore research facility reports do not include these animals. As a result of this situation, a blank report, or one with few animals listed, does not mean that a facility has not performed experiments on non-reportable animals. A blank form does mean that the facility in question has not used covered animals (primates, dogs, cats, rabbits, guinea pigs, hamsters, pigs, sheep, goats, etc.). Rats and mice alone are believed to comprise over 90% of the animals used in experimentation. Therefore the majority of animals used at research facilities are not even counted.

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