Air Force Research Labs, Brooks Air Force Base, TX

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Air Force Research Labs, Brooks Air Force Base, TX

DOD Funding of Animal Cruelty 2005:
N1: Physical Protection - 3

Title: Functional Assessment of Laser Retinal Injury in the Non-Human Primate (Macaca mulatta) Using Two Metrics of Function (visual acuity/contrast sensitivity and multifocal electroretinogram)

Research Category:

FY: 2005 Funding (in dollars): $300,000

Responsible Organization: AIR FORCE RESEARCH LAB/BROOKS
Primary Contact: US Army Medical Research Detachment of the Walter Reed Army Institute of Research
City: Brooks City-Base
State: TX
Zip: 78235-5116

Keywords: LABORATORY ANIMALS LASER MULTIFOCAL ELECTRORETINOGRAM OCULAR EYE RETINA VISUAL ACUITY CONTRAST SENSITIVITY

Objective: An objective of this research is to determine the sensitivity to retinal injury of retinal electrophysiologic testing with the multifocal electroretinogram (mfERG). Another objective is to determine the sensitivity of behavioral testing to the same retinal injuries.

Approach: The increased use of lasers by the military has been accompanied by the need to diagnose and evaluate laser retinal injuries earlier and more completely. Research was conducted to evaluate the potential of the mfERG and behavioral testing to meet these objectives. Six rhesus monkeys underwent testing before having each eye treated with a 532 nm laser. Laser exposures included one small foveal exposure to the non-dominant eye and six perimacular exposures to the dominant eye. After laser exposure, the animals underwent four mfERG sessions; photos were taken during each of these sessions. The animals also completed numerous post-exposure behavioral test sessions.    
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Research was conducted in compliance with the Animal Welfare Act and other Federal statutes and regulations relating to the use of animals in research and was reviewed and approved by the Institute's Animal Care and Use Committee.

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Rats, mice, birds, amphibians and other animals have been excluded from coverage by the Animal Welfare Act. Therefore research facility reports do not include these animals. As a result of this situation, a blank report, or one with few animals listed, does not mean that a facility has not performed experiments on non-reportable animals. A blank form does mean that the facility in question has not used covered animals (primates, dogs, cats, rabbits, guinea pigs, hamsters, pigs, sheep, goats, etc.). Rats and mice alone are believed to comprise over 90% of the animals used in experimentation. Therefore the majority of animals used at research facilities are not even counted.

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