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Animals In Print
The On-Line Newsletter

From 22 January 2002 Issue

Non-Animal Research Models supply Data relevant to humans:

*Corrositex Assay: Artificial skin to test a chemicals burn potential.

*Agarose Diffusion Method: To study toxicity of synthetic materials; mixes human cells with test    matter inside a container. If test material is toxic, dead cells cluster around it.

*EpiDerm: Neonatal skin cells cultivated into 3-dimensional tissue to simulate human skin.

*EpiOcular: Provides an alternate cornea made from manufactured tissue.

*Epipack Test: Cloned human skin cells assess the response to a skin irritant.

*Irritection Assay, Neutral Red Bioassay, Transepithelial Passage Assay

*In vitro cell and tissue cultures that blend human tissues and computer technologies.

*Mathematical and computer modeling 

*Clinical trials & epidemiology studies

*Sophisticated computer and mathematical models

*Virtual Organs

*Post-market surveillance of drugs
U.S. GRAS (Generally Regarded Safe) database of proven ingredients

*Autopsy/biopsy studies   
Diagnostic imaging/CAT, PET, MRI scans
Anatomically correct manikins; simulators and 3-D models

The future of product safety tests & biomedical research:
Companies that have created humane and more effective alternatives:

--Microsurgical Developments created a  PVC "rat" with latex veins, organs, skin and muscle.

--Parmagene Laboratories developed human tissues/computer technologies to test drugs.

--MatTek Corporation refined a 3-dimensional epidermal model that simulates human skin.

--Physiome Sciences crafted computer models into "virtual organs" that can replace animals in pharmaceutical research.

--In 1999, Science Journal reported Researcher May Griffith's University of Ottawa study to build a human corneačthe clear outer layer of the eyečin a laboratory. American and Canadian scientists are developing human corneas to replace cadaver corneas for transplants as well as the crude Draize eye irritancy tests in which corrosive chemicals are poured into the eyes of restrained rabbits.

--In 2001, 2 British scientists created a brain scanning technique, Synthetic Aperture Magnetometry (SAM), to map regions of the brain and nervous system activated by pain.
SAM's ability to locate the source of undiagnosed chest or abdominal pain in human patients deletes the need for electrical-shock tests previously administered to animals. Dr. Qasim Aziz, of Hope Hospital, Salford said: "The work will encourage research groups to replace their current animal testing with suitable and more appropriate human studies."

--The Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) is now the official U.S. government body for validating all non-animal research models. Federal agencies are obligated to consider humane alternatives, unless they can prove an animal mode works better.

Vivisection is a dead end for animals and humans

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