U.S. Army Medical Research, Frederick, MD

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U.S. Army Medical Research, Frederick, MD

DOD Funding of Animal Cruelty 2005:
M2: Infectious Diseases - 3

Title: Demonstration of a Novel Real-Time Dosimetric Nose-Only Inhalation Exposure System using Guinea Pigs and Mice

Research Category: M2: Infectious Diseases

FY: 2005 Funding (in dollars):  $30,000

Primary Contact: MRMC: U.S. Army Medical Research Institute of Infectious Diseases
City: Fort Detrick
State: MD
Zip: 21702-5011


The objective of this study is to determine if the newly-designed rodent nose-only tower can deliver multiple doses at the same time and to compare the performance of the new system to the in-use system at USAMRIID. In addition to testing the proof of concept, the following specific hypothesis (HO) will be addressed: HOl: There is no difference in the variance of measurement of aerosol concentration parameters between the in-use and newly designed system.

 Non-technical Synopsis: Exposing animals to inhaled biological aerosols ?bioaerosols? usually imparts a mechanical process by which animal(s) are exposed to an experimental atmosphere which is breathed for a specific amount of time. The bioaerosol concentration in the experimental atmosphere is then multiplied with the total amount of air the animal breathed (or assumed to breathe) during the prescribed time of exposure to estimate an ?inhaled? dose of substance. presently, the inhaled dose received by rodents is calculated based on certain biological assumptions rather than measured. In addition, animal groups receiving different dosages are exposed during discrete ?runs? of the system. This study will test a new exposure system that has been designed to reduce identified sources of variation inherent with the present in-use system. The new system will be compared to the in-use aerosol system by exposing an equal number of mice and guinea pigs to varying doses of aerosolized ricin using either system. The older system will use predetermined time based on group assumptions; the newer system will rely on the respiratory function of each animal during the exposure paired with real-time aerosol monitoring to determine the dose for each animal. Because this is a completely new technology, this effort represents a preliminary comparison study between the older system and a newly-designed system. It is expected that the new system will improve the accuracy and precision of research requiring inhalation exposure to bioaerosols, ultimately improving the screening of medical countermeasures in in vivo models where aerosol challenge is obligatory.

Research was conducted in compliance with the Animal Welfare Act and other Federal statutes and regulations relating to the use of animals in research and was reviewed and approved by the Institute's Animal Care and Use Committee.

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Rats, mice, birds, amphibians and other animals have been excluded from coverage by the Animal Welfare Act. Therefore research facility reports do not include these animals. As a result of this situation, a blank report, or one with few animals listed, does not mean that a facility has not performed experiments on non-reportable animals. A blank form does mean that the facility in question has not used covered animals (primates, dogs, cats, rabbits, guinea pigs, hamsters, pigs, sheep, goats, etc.). Rats and mice alone are believed to comprise over 90% of the animals used in experimentation. Therefore the majority of animals used at research facilities are not even counted.

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