U.S. Army Medical Research, Frederick, MD

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U.S. Army Medical Research, Frederick, MD

DOD Funding of Animal Cruelty 2005:
M4: Medical Biological Defense - 3

Title: Simultaneous administration of the anthrax, botulinum neurotoxin A, plague, and staphylococcal enterotoxin B vaccines in Rhesus monkeys.

Research Category: M4: Medical Biological Defense

FY: 2005 Funding (in dollars): $140,000


Primary Contact: MRMC: U.S. Army Medical Research Institute of Infectious Diseases
City: Fort Detrick
State: MD
Zip: 21702-5011


The objectives of this study are as follows: 1) Determine if vaccines against anthrax, botulinum neurotoxin A, plague, and staphylococcal enterotoxin B remain efficacious when given simultaneously. 2) To obtain and archive a wide variety of diagnostic specimens with which to compare the relative abilities of established and new diagnostic assays to detect exposure to or infection with Bacillus anthracis, botulinum neurotoxin type A, staphylococcal enterotoxin B, and Yersinia pestis.

The purpose of this study is to determine the efficacy of the anthrax, botulinum neurotoxin A, plague, and staphylococcal enterotoxin B vaccines when they are administered simultaneously to the skin of Rhesus macaques, and to provide tissue samples to help in the generation of an archive of specimens representing successive stages in bio-threat agent-induced disease pathogenesis. X

Research was conducted in compliance with the Animal Welfare Act and other Federal statutes and regulations relating to the use of animals in research and was reviewed and approved by the Institute's Animal Care and Use Committee.

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Rats, mice, birds, amphibians and other animals have been excluded from coverage by the Animal Welfare Act. Therefore research facility reports do not include these animals. As a result of this situation, a blank report, or one with few animals listed, does not mean that a facility has not performed experiments on non-reportable animals. A blank form does mean that the facility in question has not used covered animals (primates, dogs, cats, rabbits, guinea pigs, hamsters, pigs, sheep, goats, etc.). Rats and mice alone are believed to comprise over 90% of the animals used in experimentation. Therefore the majority of animals used at research facilities are not even counted.

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