U.S. Army Medical Research, Frederick, MD

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U.S. Army Medical Research, Frederick, MD

DOD Funding of Animal Cruelty 2005:
M4: Medical Biological Defense - 5

Title: Protective efficacy of live attenuated anthrax vaccines in guinea pigs

Research Category: M4: Medical Biological Defense

FY: 2005 Funding (in dollars):  $20,000

Primary Contact: MRMC: U.S. Army Medical Research Institute of Infectious Diseases
City: Fort Detrick
State: MD
Zip: 21702-5011


Preliminary data shows that capsule provided by an attenuated PA-producing vaccine strain increases guinea pig survival when compared to the same strain producing only PA. The objectives of this research are to confirm protection by the encapsulated strain and compare efficacy to the current approved human vaccine (AvA), the next generation vaccine (rPA), and to the licensed animal vaccine (B. anthracis Sterne

Preliminary work with guinea pigs suggests that a weakened B. anthracis strain induces better immunity when it has a capsule than when it does not. We propose to compare protection in guinea pigs given the encapsulated strain with the currently licensed protein vaccine (AVA), an improved protein vaccine (rPA), and the licensed animal vaccine (B. anthracis Sterne).

Research was conducted in compliance with the Animal Welfare Act and other Federal statutes and regulations relating to the use of animals in research and was reviewed and approved by the Institute's Animal Care and Use Committee.

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Rats, mice, birds, amphibians and other animals have been excluded from coverage by the Animal Welfare Act. Therefore research facility reports do not include these animals. As a result of this situation, a blank report, or one with few animals listed, does not mean that a facility has not performed experiments on non-reportable animals. A blank form does mean that the facility in question has not used covered animals (primates, dogs, cats, rabbits, guinea pigs, hamsters, pigs, sheep, goats, etc.). Rats and mice alone are believed to comprise over 90% of the animals used in experimentation. Therefore the majority of animals used at research facilities are not even counted.

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