University of Michigan, Ann Arbor, MI

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Stop Animal Exploitation NOW!
S. A. E. N.
"Exposing the truth to wipe out animal experimentation"

Government Grants Promoting Cruelty to Animals

University of Michigan, Ann Arbor, MI

JAMES H. WOODS - Primate Testing - 2006

Grant Number: 5P01DA000254-35
Project Title: Narcotic Drug and Opioid Peptide Basic Research project
PI Information: PROFESSOR JAMES H. WOODS, [email protected] 

Abstract: DESCRIPTION (provided by applicant): The Narcotic Drug and Opioid Peptide Basic Research Project enters its 31st year with continued vigor and enthusiasm. Several aspects of the Center are logical extensions of efforts of earlier years; other aspects represent entirely new areas of interest. Included in the former category are studies that refine and analyze the pharmacological effects of opioids in the rhesus monkey. Our research on the analgesic, respiratory, and reinforcing effects of opioids will continue into new avenues. In addition, studies using newly developed analgesia are included that may provide evidence for novel, additional pathways through which opioids can provide therapeutic action against pain and inflammatory processes. Similarly, studies of the reinforcing effects of opioids will be extended to new procedures that may provide evidence of increasing reinforcing effects of opioids during withdrawal and eventually, protracted withdrawal. The drug discovery program will continue to evaluate the in vivo and in vitro effects of opioids in rodents and in vivo effects of opioids in nonhuman primates. One objective of this aspect of the Center is to determine the mechanism by which buprenorphine exerts its novel actions that make it an extremely interesting pharmacotherapy for opioid abuse. The work of the human behavioral pharmacology laboratory continues on the focus of the evaluation of buprenorphine as a pharmacotherapy and makes direct comparison to methadone in some its pharmacology. Studies utilizing labeled carfentanil in PET imaging studies will compare buprenorphine's binding to central mu-receptors with its antagonism of hydromorphone's pharmacological effects. A new area of research is a major chemical venture toward the development of radiolabeled PET ligands specific to opioid function in pharmacologicical, physiological, and pathophysiological Conditions in primates and humans.

Thesaurus Terms:
drug design /synthesis /production, endogenous opioid, opiate alkaloid, opioid receptor, pharmacokinetics
clinical research, human subject

3003 SOUTH STATE STREET, Room 1040
ANN ARBOR, MI 481091274
Fiscal Year: 2006
Project Start: 15-JUL-1997
Project End: 30-JUN-2007

Drug Alcohol Depend. Author manuscript; available in PMC 2006 February 7.
PMCID: PMC1361278
Published in final edited form as:
Drug Alcohol Depend. 2005 February 14; 77(2): 161–168.
doi: 10.1016/j.drugalcdep.2004.07.014.
Copyright notice and Disclaimer

Reinforcing and discriminative stimulus effects of 1-benzylpiperazine and trifluoromethylphenylpiperazine in rhesus monkeys

W.E. Fantegrossi,a* G. Winger,a J.H. Woods,a W.L. Woolverton,b and A. Coopc

2.1. Animals
2.1.1. Self-administration experiments.
Adult rhesus monkeys (n = 3 for BZP alone and in combination with TFMPP, n = 4 for TFMPP) served as subjects. All animals weighed between 6.5 and 12 kg and had extensive drug self-administration histories prior to the initiation of the present studies. Animals were individually housed in stainless steel cages fitted with operant panels, and each monkey wore a Teflon mesh jacket (Lomir, Québec, Canada) connected to a flexible stainless steel spring arm attached to the rear of the cage. Animals were fed Purina monkey chow twice per day, and water was available ad libitum. Daily fresh fruit and other treats supplemented this diet. In accordance with IACUC requirements, environmental enrichment toys were also provided on a regular rotating basis.

Restrictive Teflon Mesh Jackets used in these experiments

2.1.2. Drug discrimination experiments. Adult rhesus monkeys (Macaca mulatta; n = 3, two males and one female) served as subjects. All monkeys had extensive drug histories prior to the start of the present studies. Monkeys were individually housed in stainless steel cages with water available continuously. Feeding consisted of 110–200 g of Teklad Monkey Chow approximately 3 h after each session and a chewable vitamin tablet 3 days/week.

2.2. Procedure
2.2.1. Self-administration procedure. Subjects had been previously implanted with indwelling intravenous catheters in either an internal or external jugular, femoral, or brachial vein under ketamine (10 mg/kg, i.m.) and xylazine (2 mg/kg i.m.) anesthesia. Catheters were run subcutaneously from the site of implantation to an exit site in the middle of the back. Tubing was then fed through the steel spring arm and passed to the outside rear of the cage where it was connected to drug supplies and additional infusion lines that passed through the rollers of the infusion pump. Operation of the infusion pump delivered 1 ml of drug solution over 5 s.

Two 60-min experimental sessions were conducted each day: a morning session starting at 10:00 h and an afternoon session starting at 16:00 h. The onset of each session was signaled by illumination of a red stimulus light. In the presence of this light, the 10th response on the lever beneath it resulted in the operation of the infusion pump (FR10). During the 5-s infusion duration, the red stimulus light was extinguished, the center green light was illuminated, and further lever presses had no programmed consequences. Immediately following the termination of each infusion, all stimulus lights were extinguished for a 1-min timeout period (TO 1 min) during which lever presses continued to have no programmed consequences. Each TO period counted toward the total 60-min session time.

Please email:  JAMES H. WOODS, [email protected]  to protest the inhumane use of animals in this experiment. We would also love to know about your efforts with this cause: [email protected]

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Rats, mice, birds, amphibians and other animals have been excluded from coverage by the Animal Welfare Act. Therefore research facility reports do not include these animals. As a result of this situation, a blank report, or one with few animals listed, does not mean that a facility has not performed experiments on non-reportable animals. A blank form does mean that the facility in question has not used covered animals (primates, dogs, cats, rabbits, guinea pigs, hamsters, pigs, sheep, goats, etc.). Rats and mice alone are believed to comprise over 90% of the animals used in experimentation. Therefore the majority of animals used at research facilities are not even counted.

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