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Facility Reports and Information

Air Force Research Laboratory, Wright-Patterson AFB, OH

DOD Funding of Animal Cruelty 2005: Evaluation of the Reproductive Toxicity and Teratogenicity of Sodium Tungstate in the Rat (Rattus norvegicus)

Title: Evaluation of the Reproductive Toxicity and Teratogenicity of Sodium Tungstate in the Rat (Rattus norvegicus)

Research Category:

FY: 2005 Funding (in dollars): 111,000

Primary Contact: See Responsible Organization Information
City: Wright-Patterson AFB
State: OH
Zip: 45433-7902


Objective: The objective of the proposed study is to determine the effect of sodium tungstate exposure on male and female rat reproduction and neurobehavior, and pup development and neurobehavior. Information gained in this study will be used for characterizing possible human health risks associated with oral exposure to tungsten-contaminated food and water sources from military activities and chronic intake of tungsten-containing anti diuretic drugs.

Approach: The reproductive toxicity of orally administered tungsten was investigated. Female and male test subjects were orally dosed with 125 mg/(kg day), 62.5 mg/(kg day) or 5 mg/(kg day) of sodium tungstate or dH2O (n=40/(sex group) for 70 consecutive days. The test subjects were mated after 14 days and dosing continued through pregnancy up to post-natal day (PND) 21. The gestational effects of oral sodium tungstate as well as early growth and development of the offspring were measured.

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Rats, mice, birds, amphibians and other animals have been excluded from coverage by the Animal Welfare Act. Therefore research facility reports do not include these animals. As a result of this situation, a blank report, or one with few animals listed, does not mean that a facility has not performed experiments on non-reportable animals. A blank form does mean that the facility in question has not used covered animals (primates, dogs, cats, rabbits, guinea pigs, hamsters, pigs, sheep, goats, etc.). Rats and mice alone are believed to comprise over 90% of the animals used in experimentation. Therefore the majority of animals used at research facilities are not even counted.

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