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Stop Animal
Exploitation NOW!
S. A. E. N.
"Exposing the truth to wipe
out animal experimentation"

Government Grants Promoting Cruelty to Animals
Vanderbilt University, Nashville, TN
JEFFREY D. SCHALL - Primate Testing - 2006
Grant Number: 5R01MH055806-10
Project Title: NEURAL CONTROL OF VOLUNTARY MOVEMENT
PI Information: PROFESSOR JEFFREY D. SCHALL, [email protected]
Abstract:
The long-term goal of our research is to understand how the brain
controls and monitors the actions it produces. The activity of ensembles
of neurons will be monitored in monkeys performing countermanding
(stopping) tasks. Experiments will manipulate the properties and context
of the stop signal. The frontal eye field will be studied to further
elucidate the neural activity that species whether and when a movement
will occur. The supplementary eye field and anterior cingulate cortex
will be studied to characterize the neural concomitants of supervisory
control signals. Patterns of ensemble neural activity will be analyzed
to evaluate specific hypothesis about how the brain prepares and
initiates movements (Aim 1), monitors the consequences of movements (Aim
2) and generates supervisory control signals (Aim 3). Understanding how
the brain control normal action in necessary to understand the causes of
dyscontrol underlying various psychopathologies.
Thesaurus Terms:
brain electrical activity, eye movement, neural information processing,
neuroregulation, sensory signal detection, visual field action
potential, cingulate gyrus, neurophysiology, neuropsychology, operant
conditioning, psychomotor reaction time, reinforcer, saccade, smooth
pursuit eye movement, visual fixation, visual pathway, visual stimulus,
visual threshold Macaca, histology, magnetic resonance imaging, single
cell analysis, tissue /cell preparation
Institution: VANDERBILT UNIVERSITY
Medical Center, NASHVILLE, TN 372036869
Fiscal Year: 2006
Department: PSYCHOLOGY
Project Start: 01-JUN-1996
Project End: 30-APR-2007
ICD: NATIONAL INSTITUTE OF MENTAL HEALTH
IRG: IFCN
J Neurophysiol 66: 530-558, 1991
Neuronal activity related to visually guided saccadic
eye movements in the supplementary motor area of rhesus monkeys
J. D. Schall
Department of Brain and Cognitive Sciences, Massachusetts Institute of
Technology, Cambridge 02139
Task
By the use of operant conditioning techniques, the monkeys were
trained to perform a fo/no-go visual tracking task. The monkeys were
water deprived in their home cage and were rewarded with apple juice.
The animals’ fluid intake was closely monitored; if on any day they did
not perform the task until satiated, supplemental fluid was given.
Surgery
All surgical procedures were accomplished with the animal under
barbiturate anesthesia (pentobarbital sodium, 30 mg/kg) and with the use
of sterile surgical techniques. Initially, a scleral search coil was
implanted suconjunctivally and a stainless steel post to restrain the
head was attached to the skull with acrylic cement. Once the task was
mastered to a criterion of 90% correct, a recording chamber was
implanted over a midline craniotomy that exposed SMA. |
Please email: JEFFREY D.
SCHALL,
[email protected] to protest the inhumane use of animals in this
experiment. We would also love to know about your efforts with this
cause:
[email protected]
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Rats, mice, birds, amphibians and other animals have
been excluded from coverage by the Animal Welfare Act. Therefore research
facility reports do not include these animals. As a result of this
situation, a blank report, or one with few animals listed, does not mean
that a facility has not performed experiments on non-reportable animals. A
blank form does mean that the facility in question has not used covered
animals (primates, dogs, cats, rabbits, guinea pigs, hamsters, pigs,
sheep, goats, etc.). Rats and mice alone are believed to comprise over 90%
of the animals used in experimentation. Therefore the majority of animals
used at research facilities are not even counted.
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