Vegan Health ArticlesAlzheimer's Disease: Functional Therapeutics in Neurodegenerative Disease
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Inhibition of Glutamate Release/NMDA Stimulation

By David Perlmutter, M.D.

A number of protective agents are thought to act by inhibiting either the release of glutamate or the subsequent stimulation of the NMDA receptor. These include the anti-convulsants gabapentin, lamotrigene, diphenylhydantoin, carbanazepine, and riluzole, a pharmaceutical agent developed for the treatment of amyotrophic lateral sclerosis. Huperzine A, an ancient Chinese herbal medicine (Qian Ceng Tan), was recently described in the Journal of the American Medical Association as a possible new therapy for Alzheimer’s disease. In addition to having acetylcholinesterase inhibition activity, Huperzine A specifically inhibits glutamate stimulation of the NMDA receptor.[31]

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