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Elias Zerhouni

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weeds-left weeds-right Dr. Elias Zerhouni
Former NIH director, 2002 – 2008, speaking before the NIH Scientific Review Management Board on June 4, 2013

“We have moved away from studying human disease in humans,” he lamented. “We all drank the Kool-Aid on that one, me included.” With the ability to knock in or knock out any gene in a mouse—which “can’t sue us,” Zerhouni quipped—researchers have over-relied on animal data.

“The problem is that it hasn’t worked, and it’s time we stopped dancing around the problem…We need to refocus and adapt new methodologies for use in humans to understand disease biology in humans.”