Researchers demonstrated success of an in vitro model of bone remodeling utilizing primary human cells, effectively addressing previous experimental challenges and making important progress for bone disorder research.
Study in a Sentence: Researchers demonstrated
success of an in vitro model of bone remodeling utilizing primary
human cells, effectively addressing previous experimental challenges
and making important progress for bone disorder research.
Healthy for Humans: The advancement of
human-specific bone models paves the way for a better understanding
of human bone-related pathologies, such as osteoporosis.
Bone-on-a-chip models hold immense promise for understanding the
biological mechanisms of bone remodeling and for enhancing safety
and effectiveness of therapeutics through more predictive drug
testing.
Redefining Research: Animal models often fall short
in accurately predicting results observed in human clinical trials.
The human-based components used in this novel approach help it
overcome these limitations, offering a valuable tool for tailoring
drugs to individual patients without interspecies differences.
Reference
Vis MAM, Zhao F, Bodelier ESR, et al. Osteogenesis and osteoclastogenesis on a chip: Engineering a self-assembling 3D coculture. Bone. 2023;173:116812. doi:10.1016/j.bone.2023.116812.