veggies.jpg (6769 bytes)fruitbowl.jpg (6391 bytes)Alzheimer's Disease: Functional Therapeutics in Neurodegenerative Disease

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Alzheimer's Disease: Functional Therapeutics in Neurodegenerative Disease
David Perlmutter, M.D.

Functional Intervention

The energy-linked excitotoxic model described above reveals multiple targets of susceptibility whereby compromised function can begin a progressive, feed-forward and thus self-perpetuating cascade ultimately culminating in neuronal death. These include excessive glutamate leading to excessive NMDA receptor stimulation (as noted in cerebral ischemia and amyotrophic lateral sclerosis); enhanced NMDA receptor sensitivity to glutamate as a consequence of altered electro-chemical gradient due to decreased mitochondrial ATP production (as noted in idiopathic Parkinsonís disease, MPTP-induced Parkinsonism, Huntingtonís chorea, Alzheimerís disease, and various inherited mitochondropathies); formation of NMDA receptor antibodies allowing persistent cellular inflow of calcium (noted in amyotrophic lateral sclerosis); enhanced nitric oxide production (as noted in Parkinsonís disease, Alzheimerís disease, animal models, multiple sclerosis animal models, and ischemic stroke); deficiencies of small molecule antioxidants and antioxidant enzymes (Huntingtonís chorea, Alzheimerís disease, amyotrophic lateral sclerosis, and Parkinsonís disease); and deficiencies of xenobiotic metabolism allowing accumulation of neuro-toxic intermediates (amyotrophic lateral sclerosis, Alzheimerís disease, and Parkinsonís disease).


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